Oct 15 2012

Dioxins transmitted by sperm


Proof that dioxins can be transmitted by sperm

Proof that dioxins can be transmitted by sperm

The scientific evidence that Dioxins are transmitted intergenerationally via sperm.
This information is of critical interest to all veterans exposed to dioxins and chemicals as well as farmers and fruit growers using the dioxins listed in this article.

Dioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm Epimutations
Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Michael K. Skinner*

Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the ability of dioxin (2,3,7,8-tetrachlorodibenzo[p]dioxin, TCDD) to promote epigenetic transgenerational inheritance of disease and DNA methylation epimutations in sperm. Gestating F0 generation females were exposed to dioxin during fetal day 8 to 14 and adult-onset disease was evaluated in F1 and F3 generation rats. The incidences of total disease and multiple disease increased in F1 and F3 generations. Prostate disease, ovarian primordial follicle loss and polycystic ovary disease were increased in F1 generation dioxin lineage. Kidney disease in males, pubertal abnormalities in females, ovarian primordial follicle loss and polycystic ovary disease were increased in F3 generation dioxin lineage animals. Analysis of the F3 generation sperm epigenome identified 50 differentially DNA methylated regions (DMR) in gene promoters. These DMR
provide potential epigenetic biomarkers for transgenerational disease and ancestral environmental exposures. Observations demonstrate dioxin exposure of a gestating female promotes epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.

Read full article at: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0031901

Enlightening reading.

As many of you will know I have asserted this for many years yet the government continually denies any knowledge or interest. My own PhD explored the likelihood of this in Australian Vietnam Vets. Seems I was right.

I have sent a copy to DVA. Please forward a copy to you local member and all you believe would benefit from this information.


Dr Kenneth J. O’Brien (PhD)
CEO: Families After Trauma Foundation
Director: Children & Grandchildren of Vietnam Veterans Network
Managing Director: More Than Normal

Permanent link to this article: http://vietnamvetssc.org.au/dioxins-transmitted-by-sperm/

1 comment

    • Jan Piazza on September 24, 2016 at 11:46 am
    • Reply

    Dear Sir:

    I am the daughter of a Vietnam Veteran and I am living with Aplastic Anemia, bone marrow failure disease. I also have hip deformities and had a hysterectomy at age 35 due to multiple fibroid cysts in my uterus. I am willing to participate in studies regarding birth defects in children of Vietnam Veterans. Please feel free to contact me asap. Thank you.

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